A comprehensive history of arynes in natural product total synthesis.
نویسندگان
چکیده
منابع مشابه
Synthesis of Phenolic Compounds by Trapping Arynes with a Hydroxy Surrogate.
Trapping of arynes with various nucleophiles provides a range of heteroatom-functionalized arene derivatives, but the corresponding reaction with water does not provide phenol derivatives. Silver trifluroacetate (AgO₂CCF₃) can nicely solve this problem. It was found that in typical organic solvent, AgO₂CCF₃ readily reacts with arynes to generate trifluoroacetoxy organosilver arene intermediate,...
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Two reactions of phenols with arynes have been developed. If LiTMP base is employed, arynes generated from aryl chlorides react with phenols to form helicenes. o-Arylation of phenols can be achieved by employing tBuONa base in the presence of AgOAc. Direct arylation of binol was achieved leading to the shortest pathway to o,o'-diarylbinols.
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ورودعنوان ژورنال:
- Chemical reviews
دوره 112 6 شماره
صفحات -
تاریخ انتشار 2012